Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1998-01-23
2000-09-05
Weddington, Kevin E
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 8, 514152, 514311, A61K 3170, A61K 3816, A61K 3165, A61K 3147
Patent
active
061143103
ABSTRACT:
Compounds are described which have efflux pump inhibitor activity. Also described are methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such compounds.
REFERENCES:
Ahmed et al., "A Protein That Activates Expression of a Multidrug Efflux Transporter upon Binding the Transporter Substrates," J. Biol. Chem. (1994).
Bailey, P.D., Introduction to Peptide Chemistry, John Wiley and Sons, NY, NY (1992).
Bergeron, M.G., "A Review of Models for the Therapy of Experimental Infections," Scand. J. Infect. Dis. Suppl. 14:189-206 (1978).
Bodanszky, M., et al., Practice of Peptide Synthesis, Springer-Verlag, NY, NY (1984).
Coppola, G.M., et al., Asymmetric Synthesis: Construction of Chiral Molecules Using Amino Acids, John Wiley and Sons, NY, NY (1987).
Davis, "Activity of Gentamicin, Tobramycin, Polymyxin B, and Colistimethate in Mouse Protection Tests with Pseudomonas Aeruginosa," Antimicrob. Agents Chemother. 8:50-53 (1975).
Day et al., "A Simple Method for the Study In Vivo of Bacterial Growth and Accompanying Host Response," J. Infect. 2:39-51 (1980).
Gilman et al., Eds., The Pharmacological Basis of Therapeutics, 8.sup.th Ed., Pergamon Press (1990).
Gordon, E.M., et al., "Design of Novel Inhibitors of Aminopeptidases. Synthesis of Peptide-Derived Diamino Thiols and Sulfur Replacement Analogues of Bestatin," J. Med. Chem. 31:2199-2210 (1988).
Greene, T., and P. Wuts, Protective Groups in Organic Synthesis, 2.sup.nd Edition, John Wiley & Sons, Inc. (Index) (1991).
Greenstein, J.P. and M. Wintz, Chemistry of the Amino Acids, Wiley and Sons, Inc., NY, NY (1961).
Jones, J., The Chemical Synthesis of Peptides, Oxford University Press, NY, NY (1991).
Kelly et al., "Surface Characteristics of Pseudomonas Aeruginosa Grown in a Chamber Implant Model in Mice and Rats," Infect. Immun. 57:344-350 (1989).
Larock, R., Comprehensive Organic Transformations: A Guide to Functional Group Preparations, VCH Publishers (Index) (1989).
Lorian (editor), "Laboratory Methods Used to Assess the Activity of Antimicrobial Combinations," in Antibiotics in Laboratory Medicine, Fourth Edition, Williams & Wilkins, pp. 333-338 (1996).
Malouin et al., "Outer Membrane and Porin Characteristics of Serratia Marcescens Grown In Vitro and in Rat Intraperitoneal Diffusion Chambers," Infect. Immun. 58:1247-1253 (1990).
Murray, "Can Antibiotic Resistance Be Controlled," New Engl. J. Med. 330: 1229-1230 (1994).
NCCLS publication entitled "Methods for Dilution Antimicrobial Susceptibility Test for Bacteria that Grow Aerobically--Fourth Edition: Approved Standard," NCCLS Document M7-A4, vol. 17, No. 2 (1997).
Nikaido, H., "Prevention of Drug Access to Bacterial Targets: Permeability Barriers and Active Efflux," Science 264:382-388 (1994).
Ocain, T.D., et al., "Synthesis of Sulfur-Containing Analogues of Bestatin. Inhibition of Aminopeptidases by .alpha.-Thiolbestatin Analogues," J. Med. Chem., 31:2193-2199 (1988).
Reitz et al., "The Biochemical Mechanisms of Resistance by Streptococci to the Antibiotics D-Cycloserine and O-Carbamyl-D-serine," Biochem. J. 6: 2561 (1967).
Remington's Pharmaceutical Sciences, 18.sup.th Ed., Mack Publishing Co., Easton, PA (Index) (1990).
Santoro and M.E. Levinson, "Rat Model of Experimental Endocarditis," Infect. Immun. 19:915-918 (1978).
Sato, K. et al., "Antimicrobial Activity of DU-6859, a New Potent Fluoroquinolone, Against Clinical Isolates," Antimicrob Agents Chemother. 37:1491-98 (1992).
Seoane and Levy, "Reversal of MarR Binding to the Regulatory Region of the marRAB Operon by Structurally Unrelated Inducers," Abstr. of the Am. Society for Microbiol. Gen. Meeting, Las Vegas, NV, Abstr. H-26 (1994).
Speer et al., "Bacterial Resistance to Tetracycline: Mechanisms, Transfer, and Clinical Significance," Clin. Microbiol. Rev. 5: 387-399 (1992).
Spratt, B.G., "Resistance to Antibiotics Mediated by Target Alterations," Science 264:388 (1994).
Tanaka, M. et al., "Antimicrobial Activity of DV-7751a, a New Fluoroquinolone," Antimicrob. Agents Chemother . 37 :2212-18 (1992).
Vogelman et al., "In Vivo Postantibiotic Effect in a Thigh Infection in Neutropenic Mice," J. Infect. Dis. 157:287-298 (1988).
Williams, R.M., Synthesis of Optically Active .alpha.-Amino Acids, Pergamon Press, Oxford, U.K. (1989).
Wu et al., "An Efficient Method for the Preparation of .omega.,.omega.-BIS-Urethane Protected Arginine Derivatives," Synth. Comm., 23:3055 (1993).
Xue et al., "Novel Synthesis of N.alpha.-Methyl-arginine and N.alpha.-Methyl-ornithine Derivatives," Tetrahedron Lett., 36:55 (1995).
Chamberland Suzanne
Lee May
Lee Ving J.
Leger Roger
Renau Thomas
Microcide Pharmaceuticals, Inc.
Weddington Kevin E
LandOfFree
Efflux pump inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Efflux pump inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Efflux pump inhibitors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2212243