Efficient microcapsule preparation and method of use

Details Efficient microcapsule preparation and method of use Efficient microcapsule preparation and method of use

1990-10-02

1993-08-24

Stoll, Robert L.

Coating processes

Particles, flakes, or granules coated or encapsulated

Solid encapsulation process utilizing an emulsion or...

4272133, 424497, 424426, 424 9, 424 5, B01J 1312, A61K 952

Patent

active

052387143

ABSTRACT:
The present invention relates to a method of preparing microcapsules suitable for encapsulation of therapeutic and diagnostic agents. The capsular coats are prepared from biodegradable polymers. In a particular aspect of the invention, surface charge of the polymeric material is altered by conjugation of an amino acid ester to the polymer, providing targeting to specific tissue cells. Encapsulation of hydrophilic radiodiagnostic agents in 1 .mu.m capsules provides improved opacification. Encapsulation of cytotoxic agents in 100 .mu.m capsules is useful in chemoembolization procedures.

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Dialog Search-Abstracts of references relating to microencapsulation and sustained drug delivery.
Dialog Search-Abstracts of references relating to microencapsulation of therapeutic agents.

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