Efficient methods for producing anti-microbial cationic...

Details Efficient methods for producing anti-microbial cationic... Efficient methods for producing anti-microbial cationic...

2005-09-20

2005-09-20

Weber, Jon (Department: 1653)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S325000, C435S252300, C435S252330, C514S012200, C514S013800, C530S300000, C530S324000, C536S023100, C536S023400

Reexamination Certificate

active

06946261

ABSTRACT:
Endogenously produced cationic antimicrobial peptides are ubiquitous components of host defenses in mammals, birds, amphibia, insects, and plants. Cationic peptides are also effective when administered as therapeutic agents. A practical drawback in cationic peptide therapy, however, is the cost of producing the agents. The methods described herein provide a means to efficiently produce cationic peptides from recombinant host cells. These recombinantly-produced cationic peptides can be rapidly purified from host cell proteins using anion exchange chromatography.

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