Efficient method for the synthesis of N-cyclic maleamic acids an

Details Efficient method for the synthesis of N-cyclic maleamic acids an Efficient method for the synthesis of N-cyclic maleamic acids an

1998-06-02

1999-10-12

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548545, 548547, 548548, 548549, 548550, C07D207325, C07D207452, C07D40900, C07D20740

Patent

active

059657464

ABSTRACT:
Provided are methods for the synthesis of N-cyclic maleamic acids and N-cyclic maleimide derivatives, as well as N-cyclic maleamic acids and N-cyclic maleimides synthesized thereby. The method for synthesis of an N-cyclic maleamic acid involves reacting an amino group-containing N-cyclic compound with maleic anhydride in acetic acid to obtain an N-cyclic maleamic acid. An N-cyclic maleimide can be formed by adding hexamethyldisilazane to an N-cyclic maleamic acid prepared according to the above-described method, thereby cyclizing a maleamic acid site of the N-cyclic maleamic acid. The described methods allow for the products to be obtained at high yields.

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