Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1987-12-09
1992-06-02
Brown, Johnnie R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530413, 530416, 530417, 530418, 530808, 530830, 424 858, 210635, 210656, A61K 3514, C07K 300, B01D 1508
Patent
active
051187965
ABSTRACT:
Improved methods for direct purification of product immunoglobulins or their derivatives from large volumes of mammalian cell culture medium include directly subjecting the cell culture medium to cation exchange treatment, so as to adsorb the product but not the contaminants. The eluted product is then recycled, or is applied to anion exchange, for further purification, and optionally subjected to additional steps. The product may be obtained in a form suitable for clinical applications, if desired.
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Duffy Stephen A.
Moellering Billy J.
Prior Christopher P.
Brown Johnnie R.
Centocor Incorporated
Mohamed Abdel A.
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