Efficient functionalization of porphyrin derivatives possessing

Details Efficient functionalization of porphyrin derivatives possessing Efficient functionalization of porphyrin derivatives possessing

1997-07-07

1998-08-04

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540145, 540465, 540474, 534 11, 534 12, 534 13, 534 15, C07D48722

Patent

active

057895864

ABSTRACT:
A method for preparing functionalized derivatives of organic or inorganic compounds and tetrapyrrolic compounds in particular, all of which compounds have at least one sulfonic acid group, by first preparing a sulfonyl halide intermediate of the compound then reacting the intermediate with a second compound having a reactive hydroxyl or amine group to yield the desired sulfonylamide or sulfonic esters thereof. The method may be used to produce a variety of photosensitive compounds having different functionality. For example, sulfonamide or sulfonic ester reaction products of the tetrapyrrolic compounds or other photosensitive organic molecules may exhibit an enhanced ability to localize at a particular target site for phototherapy. The method provides means for altering the functionality of sulfonic acid-containing photosensitive compounds to produce derivatives thereof which may aid in the detection and/or phototherapy of diseased sites or provide functionality having enhanced affinity and exhibiting improved binding to site specific receptors within a diseased target tissue such that the therapy is improved.

REFERENCES:
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patent: 5281616 (1994-01-01), Dixon et al.
patent: 5484915 (1996-01-01), Gregory et al.

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