Efficient enantioselective addition reaction using an organozinc

Details Efficient enantioselective addition reaction using an organozinc Efficient enantioselective addition reaction using an organozinc

1998-05-11

2000-01-18

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564443, 568807, 568812, 568813, 568840, 568843, 544 92, C07C21145, C07D26518

Patent

active

06015926&

ABSTRACT:
An efficient method for the preparation of key intermediate, in the synthesis of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-ben zoxazin-2-one, a reverse transcriptase inhibitor is achieved using a chiral addition reaction to the 4-chloro-2-trifluoromethylketoaniline with an organozinc complex to give the desired alcohol. This instant method has broad applicability in the chiral addition to any prochiral ketone.

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