Efficient chemoenzymatic synthesis of D-myo-inositol 1,4,5-triph

Details Efficient chemoenzymatic synthesis of D-myo-inositol 1,4,5-triph Efficient chemoenzymatic synthesis of D-myo-inositol 1,4,5-triph

1992-01-29

1993-11-09

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558147, 558156, 568833, 549331, 549336, 549341, 536 44, C07C 6903, C07C 6970, C07C 6714, C07F 718, C07F 7144, C07F 9655

Patent

active

052604721

ABSTRACT:
Multigram quantities of Ins(1,4,5) P.sub.3, Ins(1,3,4) P.sub.3, and Ins(1,3,4,5)P.sub.4 are prepared in their enantiomerically pure forms from the two enantiomers of 1,2:5,6-di-O-cyclohexylidene myo-inositol. Also, a facile enzymatic preparation is also described of these chiral precursors through enantiospecific deacylation of the corresponding racemic esters is disclosed.

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Vacca et al, J. Amer. Chem. Soc., vol. 109, pp. 3478-3479 (1987).

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