Efficient and stable in vivo gene transfer to...

Details Efficient and stable in vivo gene transfer to... Efficient and stable in vivo gene transfer to...

2006-07-18

2006-07-18

Chen, Shin-Lin (Department: 1632)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C424S093210, C435S320100, C435S455000, C536S023100, C536S023500, C536S024100

Reexamination Certificate

active

07078387

ABSTRACT:
This invention relates to the use of recombinant adeno-associated virus (rAAV) vectors to transduce cardiomyocytes in vivo by infusing the rAAV into a coronary artery or coronary sinus. rAAV infection is not associated with detectable myocardial inflammation or myocyte necrosis. Thus, rAAV is a useful vector for the stable expression of therapeutic genes in the myocardium and can be used to deliver genes for inducing angiogenesis, inhibiting angiogenesis, stimulating cell proliferation, inhibiting cell proliferation and/or treating or ameliorating other cardiovascular conditions.

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