Radiation imagery chemistry: process – composition – or product th – Electric or magnetic imagery – e.g. – xerography,... – Radiation-sensitive composition or product
Patent
1998-06-18
2000-08-29
Riley, Jezia
Radiation imagery chemistry: process, composition, or product th
Electric or magnetic imagery, e.g., xerography,...
Radiation-sensitive composition or product
430581, 435 6, 436519, 536 2532, 548427, G03G 1508, G03C 1005, C12Q 168, C07H 2100, C07D20956
Patent
active
061106305
ABSTRACT:
Activating groups based on N-hydroxynaphthalimide, are disclosed herein. The activating groups can mediate the coupling of labeling moieties, such as biotin or cyanine dyes, to a variety of components, including chain terminators, nucleoside triphosphates, and oligonucleotides, which are used in nucleotide sequencing. From these activating groups, activated esters of the labeling moieties can be prepared. The activated esters react with a component, for example a derivatized nucleotide chain terminator, to give a labeled component. In additions, methods of the present invention provide for labeling a nucleoside triphosphate in organic media. The activating groups and methods of the present invention allow the activation and coupling reactions to occur at a much higher yield, compared with the prior art.
REFERENCES:
patent: 4337063 (1982-06-01), Mihara et al.
patent: 4404289 (1983-09-01), Masuda et al.
patent: 4405711 (1983-09-01), Masuda et al.
patent: 4711955 (1987-12-01), Ward et al.
patent: 4981977 (1991-01-01), Southwick et al.
patent: 5047519 (1991-09-01), Hobbs, Jr. et al.
patent: 5151507 (1992-09-01), Hobbs, Jr. et al.
patent: 5242796 (1993-09-01), Prober et al.
patent: 5268486 (1993-12-01), Waggoner et al.
patent: 5348868 (1994-09-01), Reddy et al.
patent: 5428148 (1995-06-01), Reddy et al.
patent: 5486616 (1996-01-01), Waggoner et al.
patent: 5491059 (1996-02-01), Whitcomb
patent: 5569587 (1996-10-01), Waggoner et al.
patent: 5569766 (1996-10-01), Waggoner et al.
patent: 5627027 (1997-05-01), Waggoner et al.
Bhat, V., et al., "A Simple and Convenient Method for the Selective N-Acylations of Cytosine Nucleosides", Nuclosides & Nucleotides, 8(2):179 (1989).
Ernst. L.A., et al., "Cynanine Dye Labeling Reagents for Sulfhydryl Groups", Cytometry, 10:3 (1989).
Fieser, et al., Reagent for Organic Synthesis, vol. 1, 485-6, (1967).
Mujumder, R.J., et al., "Cyanine Dye Labeling Reagents: Sulfoindocyanine Succinimidyl Esters", Bioconjugate Chemistry, 4(2):105 (1993).
Mujumder, S.R., et al., "Cyanine-Labeling Reagents: Sulfobenzindocyanine Succinimidyl", Bioconjugate Chemistry, 7(2):356 (1996).
Farooqui Firdous
Hanna Naeem B.
Michael Maged A.
Reddy M. Parameswara
Beckman Coulter Inc.
Kivinski Margaret A.
May William H.
Riley Jezia
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