Efficacious vaccines against bordetella pertussis comprising a c

Details Efficacious vaccines against bordetella pertussis comprising a c Efficacious vaccines against bordetella pertussis comprising a c

1995-05-22

1999-03-23

Spiegel, Carol A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4241841, 4242381, 4242391, 4242531, 4242561, 4242471, A61K 3905, A61K 3908, A61K 3910, A61K 39102

Patent

active

058855866

ABSTRACT:
This invention is directed to a vaccine for the prevention of disease caused by Bordetella pertussis which comprises the pertussis antigens filamentous hemagglutinin, detoxified lymphocytosis promoting factor and a 69 kilodalton outer membrane protein, where said antigens are individually purified prior to being combined to form the vaccine. The invention is further directed to pertussis vaccines where the antigens are combined in any ratio, including ratios not possible in whole cell or co-purified acellular pertussis vaccines. The pertussis antigens may be further combined with other individually purified pertussis antigens, pertussis structural components, adjuvants, stabilizers and non-pertussis vaccine components.

REFERENCES:
patent: 4338299 (1982-07-01), Vesselinova-Jenkins
patent: 4784589 (1988-11-01), Robinson
patent: 5276142 (1994-01-01), Gotto
patent: 5578308 (1996-11-01), Capiau et al.
Blumberg et al., J. Pediatrics, 117, 46-51 (1990).
DeMagistris et al., J. Exp. Med., 168, 1351-1362 (1988).
Mortimer et al., Am. J. Diseases of Children, 144, 899-904 (1990).
Munoz et al., Bordetella pertussis, 45-47 (M. Dekker publ. 1977).
Robinson et al., Infection and Immunity, 40, 523-528 (1983).
Robinson et al., Vaccine, 3, 11-12 (1985).
Rutter et al., Vaccine, 6, 29-32 (1988).
Shahin et al., J. Exp. Med., 171, 63-73 (1990).
Storsaeter et al., Vaccine, 8, 457-461 (1990).
Moxon et al. Lancet 335: 1324-1329, 1990.
Sarnaik et al. Pediatric Infectious Diseases Journal 9:181-6, Mar. 1990.
Cowrsaget et al. Infection and Immunity 51(3): 784-7, 1986.
Savnaik et al. Pediatric Infectious Disease Journal 9:181-6, Mar. 1990.
Coulehan et al. Journal of Infectious Diseases 148(3): 530-4, 1983.
Shahin et al. Journal of Experimental Medicine 171:63-73, 1990.
Mortimer et al. Journal of Infectious Diseases 161: 473-9, 1990.

Affiliated with

Also associated with

Rating

Efficacious vaccines against bordetella pertussis comprising a c does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Efficacious vaccines against bordetella pertussis comprising a c, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Efficacious vaccines against bordetella pertussis comprising a c will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2122608