Efficacious vaccines against Bordetella pertussis comprising a c

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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4242381, 4242391, 4242531, 4242561, A61K 3905, A61K 3908, A61K 3910, A61K 39102

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058978674

ABSTRACT:
This invention is directed to a vaccine for the prevention of disease caused by Bordetella pertussis which comprises the pertussis antigens filamentous hemagglutinin, detoxified lymphocytosis promoting factor and a 69 kilodalton outer membrane protein, where said antigens are individually purified prior to being combined to form the vaccine. The invention is further directed to pertussis vaccines where the antigens are combined in any ratio, including ratios not possible in whole cell or co-purified acellular pertussis vaccines. The pertussis antigens may be further combined with other individually purified pertussis antigens, pertussis structural components, adjuvants, stabilizers and non-pertussis vaccine components.

REFERENCES:
patent: 4338299 (1982-07-01), Vesselinova-Jenkins
patent: 4784589 (1988-11-01), Robinson
patent: 5276142 (1994-01-01), Gotto
patent: 5578308 (1996-11-01), Capiau et al.
Blumberg et al., J. Pediatrics, 117, 46-51 (1990).
DeMagistris et al., J. Exp. Med., 168, 1351-1362 (1988).
Mortimer et al., Am. J. Diseases of Children, 144, 899-904 (1990).
Munoz et al., Bordetella pertussis, 45-47 (M. Dekker publ. 1977).
Robinson et al., Infection and Immunity, 40, 523-528 (1983).
Robinson et al., Vaccine, 3, 11-12 (1985).
Rutter et al., Vaccine, 6, 29-32 (1988).
Shahin et al., J. Exp. Med., 171, 63-73 (1990).
Storsaeter et al., Vaccine, 8, 457-461 (1990).
Moxon et al. Lancet 335:1324-1329, 1990.
Coursaget et al. Infection and Immunity 51(3): 784-7, 1986.
Sarnaik et al. Pediatric Infectious Disease Journal 9:181-6, Mar. 1990.
Coulehan et al. Journal of Infectious Diseases 148 (3): 530-4, 1983.
Shahin et al. Journal of Experimental Medicine 171: 63-73, 1990.
Mortimer et al. Journal of Infectious Diseases 161: 473-9, 1990.

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