Efficacious vaccines against Bordetella pertussis comprising a c

Details Efficacious vaccines against Bordetella pertussis comprising a c Efficacious vaccines against Bordetella pertussis comprising a c

1995-05-22

1999-04-27

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4242381, 4242391, 4242531, 4242561, A61K 3905, A61K 3908, A61K 3910, A61K 39102

Patent

active

058978674

ABSTRACT:
This invention is directed to a vaccine for the prevention of disease caused by Bordetella pertussis which comprises the pertussis antigens filamentous hemagglutinin, detoxified lymphocytosis promoting factor and a 69 kilodalton outer membrane protein, where said antigens are individually purified prior to being combined to form the vaccine. The invention is further directed to pertussis vaccines where the antigens are combined in any ratio, including ratios not possible in whole cell or co-purified acellular pertussis vaccines. The pertussis antigens may be further combined with other individually purified pertussis antigens, pertussis structural components, adjuvants, stabilizers and non-pertussis vaccine components.

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