Effervescent system having an alkali-sensitive and/or metal-sens

Details Effervescent system having an alkali-sensitive and/or metal-sens Effervescent system having an alkali-sensitive and/or metal-sens

1994-04-15

1996-06-18

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424465, 424492, 424493, 424496, 424497, 5147723, 514774, 514782, 514777, A61K 946, A61K 916

Patent

active

055275400

ABSTRACT:
In the pharmaceutical formulation of at least one alkali-sensitive active substance with an effervescent system, the carbonate component is embedded in at least one edible, organic acid and is preferably covered by said acid or by another acid. The active substance is embedded in at least one of the following compounds: an edible, organic acid, a higher alcohol, a hydrocolloid or a relatively long-chain polyvinylpyrrolidone, preferably covered with at least one of the stated compounds. The contact zone between active substance and effervescent system should have a pH of not more than 4.5. Both effervescent system particles and active substance particles, which are embedded or optionally covered in this manner, may be applied to carrier crystals of the same or another acid. The mixture is preferably pressed to give tablets. The acid provided for the embedding or covering may contain 0.1 to 3 mg of ethylenediaminetetraacetic acid per tablet.

REFERENCES:
patent: 4762702 (1988-08-01), Gergely et al.
patent: 5306506 (1994-04-01), Zema et al.

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