Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1997-06-02
1999-03-30
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424489, A61K 946
Patent
active
058885447
ABSTRACT:
The effervescent system for effervescent tablets and/or effervescent granules contains, on the one hand, particles of a solid, edible, organic acid and, on the other hand, particles of at least one alkali metal bicarbonate, of which at least 1, preferably from 2 to 4, but at most 10, preferably at most 8, % by weight are superficially converted into dry alkali metal carbonate free of water of crystallization. The acid particles, preferably citric acid particles, can be covered in a manner known per se by partial reaction with at least one carbonate and/or bicarbonate, preferably from about 20 to 40% by weight thereof. The conversion mentioned is carried out by a procedure in which commercial alkali metal bicarbonate particles are heated in a vacuum vessel at less than 40, preferably less than 20, in particular less than 10, mbar at above 60.degree. C., preferably between 80.degree. C. and 120.degree. C., in particular at about 100.degree. C., and are cooled to below 60.degree. C., preferably to below 50.degree. C., after a time predetermined by the desired layer thickness, while maintaining the vacuum. The alkali metal carbonate particles evolve only a little CO.sub.2 even on storage at elevated temperature, and the formation of free salicylic acid (fSA) from any acetylsalicylic acid mixed with the effervescent system remains very small.
REFERENCES:
patent: 3105792 (1963-10-01), White
patent: 3984527 (1976-10-01), Gancy et al.
Gergely Gerhard
Gergely Irmgard
Gergely Stefan
Gergely Thomas
Gergely Gerhard
Page Thurman K.
Spear James M.
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