Effervescent ranitidine formulations

Details Effervescent ranitidine formulations Effervescent ranitidine formulations

1997-04-16

1998-03-17

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424465, 424499, A61K 946

Patent

active

057284016

ABSTRACT:
An effervescent pharmaceutical composition for oral use in the treatment of a condition mediated through histamine H.sub.2 receptors contains a therapeutically effective amount of ranitidine or a physiologically acceptable salt thereof, about 25-70% by weight of disodium citrate, and about 20-50% by weight of sodium bicarbonate. Optionally, the effervescent composition may also Include about 0.5-25% by weight of an edible organic acid such as fumaric acid. Preferably, the effervescent composition is in the form of a tablet. Additional excipients for the effervescent composition include about 2-10% by weight of glycine, a flavoring agent, a sweetening agent, a binding agent, and/or a lubricant.

REFERENCES:
patent: 4585790 (1986-04-01), Padfield et al.
patent: 4704269 (1987-11-01), Korab
patent: 4824664 (1989-04-01), Tarral et al.
patent: 4942039 (1990-07-01), Duvall et al.
patent: 5064656 (1991-11-01), Gergely et al.
patent: 5102665 (1992-04-01), Schaeffer
patent: 5164192 (1992-11-01), Louwes
patent: 5415870 (1995-05-01), Gergely et al.
patent: 5424075 (1995-06-01), Daher et al.

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