Effervescent mixture with alkali metal salts or lysinates of aci

Details Effervescent mixture with alkali metal salts or lysinates of aci Effervescent mixture with alkali metal salts or lysinates of aci

1994-09-07

1997-01-14

Seidleck, James J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424466, 424439, 424715, 424717, 514960, 514974, 514975, A61K 946

Patent

active

055936938

ABSTRACT:
The effervescent mixture contains at least one acidic, insoluble or slightly soluble pharmaceutical active ingredient in the form of its soluble alkali metal salt or lysinate, which is present as an intimate mixture with the alkaline component and preferably coats the particles of the alkaline component of the effervescent system, for example sodium bicarbonate and/or sodium carbonate. Both components in very finely powdered form may also be present as granules, with the aid of a binder. In particular, the effervescent mixture contains, per 100 parts of active ingredient, at least 0.5 part, preferably 1 to 3 parts, of a surfactant, in particular dioctyl sulfosuccinate, and/or at least 1 part, preferably 3 to 5 parts, of a binder or suspending agent, in particular polyvinylpyrrolidone. The acidic component of the effervescent system is passivated on the surface.

REFERENCES:
patent: 4678661 (1987-07-01), Gergely et al.
patent: 4888177 (1989-12-01), Gergely et al.
patent: 5064656 (1991-11-01), Gergely et al.
patent: 5306506 (1994-04-01), Zema et al.
patent: 5415870 (1995-05-01), Gergely et al.

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