Effervescent dosage form with microparticles

Details Effervescent dosage form with microparticles Effervescent dosage form with microparticles

1992-04-16

1993-01-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424 44, A61K 946

Patent

active

051788780

ABSTRACT:
A pharmaceutical dosage form incorporates microparticles which are susceptible to rupture upon chewing or which are adapted to provide substantially immediate release of the pharmaceutical ingredient contained in the microparticles. These microparticles are provided in a tablet with an effervescent disintegration agent. When the tablet is taken orally, the effervescent disintegration agent aids in rapid dissolution of the tablet and hence permits release of the microparticles, and swallowing of the microparticles, before the pharmaceutical ingredient is released from the microparticles. The system therefore provides particularly effective taste masking.

REFERENCES:
patent: 1262888 (1918-04-01), Westlake
patent: 3962417 (1976-06-01), Howell
patent: 4613497 (1986-09-01), Chaukin
patent: 4639368 (1987-01-01), Niazi
patent: 4687662 (1987-08-01), Schobel
patent: 4725427 (1988-02-01), Ashmead
patent: 4753792 (1988-06-01), Aberg
patent: 4940588 (1990-07-01), Sparks
patent: 5055306 (1991-02-01), Barry
Pharmaceutical Dosage Forms-Tablets vol. 1, 2nd edition, Herbert A. Lieberman, ed pp. 372-376.

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