Effervescent couples, histamine H.sub.2 -antagonist effervescent

Details Effervescent couples, histamine H.sub.2 -antagonist effervescent Effervescent couples, histamine H.sub.2 -antagonist effervescent

1987-01-20

1989-04-25

Robinson, Ellis P.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

424 44, 424439, 424446, A01N 2502, A61L 904

Patent

active

048246646

ABSTRACT:
The invention relates to an effervescent couple which comprises a mixture of mono-and di-alkali metal citrate as well as to a process for preparing same. The process comprises partially neutralizing citric acid by reacting an alkali metal carbonate or bicarbonate with citric acid and water and controlling the amount of carbon dioxide released during the reaction by stopping the reaction when a certain amount of citric acid has been neutralized. In a preferred embodiment the reaction is stopped when from about 24% to about 54% of the potential amount of carbon dioxide has been released.

REFERENCES:
patent: 1764996 (1930-06-01), Andrews
patent: 2147743 (1939-02-01), Levin
patent: 3887700 (1975-06-01), Boncey et al.
patent: 4289751 (1981-09-01), Windhevser
patent: 4503051 (1985-03-01), Algieri et al.
patent: 4522943 (1985-06-01), Algieri et al.
patent: 4537900 (1985-08-01), Kreidl et al.

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