Effects of growth factors on hair follicle cell proliferation an

Details Effects of growth factors on hair follicle cell proliferation an Effects of growth factors on hair follicle cell proliferation an

1991-02-04

1997-04-01

Czaja, Donald E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435243, 435244, 514 21, 514880, 530356, 623 15, A01N 102, C12N 500, A61K 3800, C07K 100

Patent

active

056164718

ABSTRACT:
The present invention relates to methods for detecting the effects of selected growth factors and pharmaceuticals on the growth and development of hair follicles by assaying hair follicle cell proliferation and cellular collagenolytic factor secretion. In particular, isolated hair follicle cells maintained as intact functioning folliculoids are embedded in a three-dimensional culture system, and exposed to the chemical agent of choice. The effect of this agent can then be determined with respect to its ability to modify cellular proliferation or secretion of proteolytic factors. Each determination involves the use of a separate assay.

REFERENCES:
Weinberg, et al., "Growth Factor Effects on Cultured Hair Follicles" J. Investigative Dermatology 94:589 (Apr. 1990).
Rogers et al J Investigative Dermatology vol. 89 No. 4 pp. 369-379.

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