Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Patent
1992-08-14
1997-11-25
Tsang, Cecilia J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
435 39, 435213, 4352401, 436 16, 436 63, 436 69, 530324, 530350, 530351, 530382, 530412, 514 2, 514 21, C12Q 156, C12Q 106, G01N 3386
Patent
active
056911602
ABSTRACT:
The present invention relates to therapeutic methods wherein an actin-binding protein, preferably gelsolin or DBP, is administered to a patient with actin-containing clots in order to remove actin from the clots. The invention also relates to diagnostic methods in which actin is removed from an actin-containing clot in vitro and quantitated.
REFERENCES:
patent: 5177001 (1993-01-01), Yamamoto
patent: 5177002 (1993-01-01), Yamamoto
patent: 5260224 (1993-11-01), Stossel et al.
patent: 5326749 (1994-07-01), Yamamoto
patent: 5464817 (1995-11-01), Stossel
patent: 5508265 (1996-04-01), Stossel
D. J. Kwiatkowski et al., "Plasma and Cytoplasmic Geloslins Are Encoded By A sSingle Gene and Contain A Duplicated Actin-Binding Molecule," Nature, 323, pp. 455-458 (1986).
D. J. Kwiatkowski et al., "Identification of Critical Functional and Regulatory Domains in Gelsolin," J. Cell Biol. 108, pp. 1717-1726 (1989).
Journey et al, Blood, vol. 80, No. 4, pp. 928-936, Aug. 15, 1992.
Lind et al, J. Clin. Invest., vol. 78, pp. 736-742, Sep. 1986.
Haddad et al, Proc. Natl. Acad. Sci. USA, vol. 87, pp. 1381-1385, Feb. 1990.
Smith et al, J. Lab. Clin. Med., vol. 110, No. 2, pp. 189-195, Aug. 1987.
Andre, E. et al., The Journal of Biological Chemistry 263(2):722-727 (1988).
Carr, M.E. et al., J. Lab. Clin. Med. 96(6):985-993 (1980).
Carr, M.E., Thrombosis and Haemostasis 59(3):535-539 (1988).
Carr, M.E. et al., J. Lab. Clin. Med. 110(6):747-752 (1987).
Carrell, N. et al., Blood 62(2):439-447 (1983).
Dhall, T.Z. et al., Thrombosis and Haemostasis 35:737-745 (1976).
Dhall, T.Z. et al., Thrombosis and Haemostasis 49(1):42-46 (1983).
Gabriel, D.A. et al., J. Lab. Clin. Med. 101(4):545-552 (1983).
Goldschmidt-Clermont, P.J. et al., Gastroenterology 94:1454-1458 (1988).
Goldschmidt-Clermont, P.J. et al., J. Clin. Invest. 81:1519-1527 (1988).
Haddad, J.G. et al., Proc. Natl. Acad. Sci. USA 87:1381-1385 (1990).
Harper, K.D. et al., Clinical Research 36(3):625A (1988).
Harper, K.D. et al., J. Clin. Invest. 79:1365-1370 (1987).
Janmey, P.A. et al., Blood 70(2):524-530 (1987).
Janmey, P.A. et al., Biochimica et Biophysica Acta 841:151-158 (1985).
Kamykowski, G.W. et al., Biophysical Chemistry 13:25-28 (1981).
Laki, K. et al., Biochimica et Biophysica Acta 371:519-525 (1974).
Lee, W.M. et al., Circulatory Shock 28:249-255 (1989).
Lee, W.M. et al., Hepatology 7(5):825-830 (1987).
Lind, S.E. et al., Am. Rev. Respir. Dis. 138:429-434 (1988).
Lind, S.E. et al., J. Clin. Invest. 78:736-742 (1986).
Pollard, T.D. et al., Ann. Rev. Biochem. 55:987-1035 (1986).
Procyk, R. et al., Biopolymers 29:559-565 (1990).
Smith, D.B. et al., American Journal of Pathology 130(2):261-267 (1988).
Smith, D.B. et al., Blood 72(1):214-218 (1988).
Smith, D.B. et al., J. Lab. Clin. Med. 110:189-195 (1987).
Stossel, T.P. et al., Ann. Rev. Cell Biol. 1:353-402 (1985).
Suenson, E. et al., Biochimica et Biophysica Acta 870:510-519 (1986).
International Search Report for International Application No. PCT/US93/07584, mailed Oct. 14, 1993.
Janmey, P.A. et al., Effects of actin filaments on fibrin clot structure and lysis, Biological Abstracts 94(10):AB-953, Abstract No. 111777 (1992).
Kawamura, K. et al., Quantivitative determination of vitamin-D-binding protein in body fluids, Chemical Abstracts 104, Abstract No. 145140w (1986).
Lind, S.E. et al., Actin Is a Noncompetitive Plasmin Inhibitor, J. Biol. Chem. 266(8):5273-5278 (1991).
Lind, S.E. et al., Human Plasma Gelsolin Binds to Fibronectin, J. Biol. Chem. 259(21):13262-13266 (1984).
Ohsawa, M., Binding of actin to serum actin-binding proteins and determination of actin in blood of cadavers using anti Gc, Chemical Abstracts 111, Abstract No. 2243r (1989).
Janmey Paul A.
Lamb Jennifer A.
Lind Stuart E.
Stossel Thomas P.
Biogen Inc.
Levine Leslie M.
Mohamed Abdel A.
Tsang Cecilia J.
LandOfFree
Effects of actin filaments of fibrin clot structure and lysis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Effects of actin filaments of fibrin clot structure and lysis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Effects of actin filaments of fibrin clot structure and lysis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2105934