Effectors of dipeptidyl peptidase IV for topical use

Details Effectors of dipeptidyl peptidase IV for topical use Effectors of dipeptidyl peptidase IV for topical use

2005-09-27

2005-09-27

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S183000, C424S094630, C424S078020, C544S141000, C548S200000, C548S400000, C548S535000

Reexamination Certificate

active

06949515

ABSTRACT:
The invention relates to compounds for topically influencing the activity of dipeptidyl peptidase of the general formulawhereinA is an amino acid having at least one functional group in the side chain;B is a chemical compound covalently bound to a functional group of the side chain of A, chosen from the group consisting of(a) oligopeptides having a chain length of up to 20 amino acids,(b) homopolymers of glycine consisting of up to 6 glycine monomers, and(c) polyethylene glycols having molar masses of up to 20 000 g/mol; andC is a group amide-bonded to A chosen from the group consisting of thiazolidine, pyrrolidine, cyanopyrrolidine, hydroxyproline, dehydroproline or piperidine.The invention further relates to the use of said compounds for targeted intervention in local immunological processes (chemotaxis, inflammatory processes, autoimmune diseases), as well as effective and targeted treatment of pathophysiological and physiological processes related thereto (psoriasis, periodontitis, arthritis, allergies, inflammation), inter alia.

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