Effect of transglutaminase inhibition on microfilariae developme

Details Effect of transglutaminase inhibition on microfilariae developme Effect of transglutaminase inhibition on microfilariae developme

1990-01-16

1992-06-23

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514400, 514663, 514673, A01N 3302, A01N 4106, A61K 3113, A61K 3118

Patent

active

051243580

ABSTRACT:
A method is described for blocking maturation and production of microfilariae in adult filarial nematodes utilizing a transglutaminase inhibitor, such as monodansyl cadaverine (MDC). Experiments applying this method to several Brugia filarial infections, including Brugia malayi, were successful. Higher concentration of transglutaminase inhibitor proved to be filariacidal.

REFERENCES:
patent: 4396628 (1983-08-01), Pastan et al.
Noble et al.; Parasitology, 2nd (1964) pp. 264-265, 270-273, 326, 327 and 350-363.

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