Effect of N,N,N-trimethylsphingosine on protein kinase-C activit

Details Effect of N,N,N-trimethylsphingosine on protein kinase-C activit Effect of N,N,N-trimethylsphingosine on protein kinase-C activit

1991-07-02

1992-09-29

Raymond, Richard L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352401, C12N 500

Patent

active

051513609

ABSTRACT:
The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors) and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, and modulating cell adhesion molecule expression and function using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory an anti-metastatic activity over related compounds.

REFERENCES:
Hannun et al., Science, vol. 235 (1987) p. 670.

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