Effect of N,N,N,-trimethylsphingosine on protein kinase C activi

Details Effect of N,N,N,-trimethylsphingosine on protein kinase C activi Effect of N,N,N,-trimethylsphingosine on protein kinase C activi

1990-12-31

1992-08-11

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564292, 564503, A61K 3114, C07C21540

Patent

active

051379198

ABSTRACT:
The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors), and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory and anti-metastatic activity over related compounds.

REFERENCES:
Hannun and Bell, "Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses," Science, 235: 670-674 (Feb. 6, 1987).
Igarashi et al., "A Specific Enhancing Effect of N,N-Dimethylsphingosine on Epidermal Growth Factor Receptor Autophosphorylation", J. Biol. Chem., 265 (10): 5385-5389 (1990).
Sommer et al., "Alkylation of Amines. A General Exhaustive Alkylation Method for the Synthesis of Quaternary Ammonium Compounds", J. Org. Chem., 36(6): 824-828 (1971).
Igarashi et al., "Effect of Chemically Well-Defined Sphingosine and Its N-Methyl Derivatives on Protein Kinase C and src Kinase Activities", Biochem. 28: 6796-6800 (1989).

Affiliated with

Also associated with

Rating

Effect of N,N,N,-trimethylsphingosine on protein kinase C activi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Effect of N,N,N,-trimethylsphingosine on protein kinase C activi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Effect of N,N,N,-trimethylsphingosine on protein kinase C activi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-346741