Effect of electric field and ultrasound for transdermal drug del

Details Effect of electric field and ultrasound for transdermal drug del Effect of electric field and ultrasound for transdermal drug del

1996-04-01

2000-03-21

Bockelman, Mark

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

604 22, 600578, A61N 130

Patent

active

060412534

ABSTRACT:
Transdermal transport of molecules during sonophoresis (delivery or extraction) can be further enhanced by application of an electric field, for example, electroporation or iontophoresis. In a preferred embodiment the ultrasound is low frequency ultrasound which induces cavitation of the lipid layers of the stratum corneum (SC). This method provides higher drug transdermal fluxes, allows rapid control of transdermal fluxes, and allows drug delivery or analyte extraction at lower ultrasound intensities than when ultrasound is applied in the absence of an electric field.

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