Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1977-03-01
1979-01-16
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
A61K 31135
Patent
active
041349970
ABSTRACT:
The compounds represented by the structural formulae: ##STR1## one each used for the treatment of warm blooded mammals with infarcted hearts.
The compounds I and II have a totally unpredictable effect on the infarcted heart. An artificial infarct (stoppage of blood vessel) is produced, to mimic the occurrence of a heart attack. Administration of a suitable amount of the compound opens new blood channels in the heart tissue, by-passing the infarcted region, and providing a supply of arterial blood to the area served by the occluded blood vessel. The necrosis which normally occurs in regions of the heart muscle as a result of a stoppage of an artery and resultant oxygen deficiency is largely prevented.
REFERENCES:
Cannon et al., J. Med. Chem., vol. 15, No. 4, pp. 348-350 (1972).
Sprehnger et al., J. Med. Chem., vol. 12, pp. 487-490 (1969).
Cannon Joseph G.
Diana John N.
Long John P.
Friedman Stanley J.
University of Iowa Research Foundation
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