EDTA and other chelators with or without antifungal antimicrobia

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 31, A01N 2500, A61K 3170

Patent

active

061654841

ABSTRACT:
A pharmaceutical composition comprising at least one antifungal agent and at least one chelator, and a method for administering the pharmaceutical composition to a patient having a fungal infection. Another aspect provides a pharmaceutical composition comprising at least one chelator, at least one antifungal agent and at least one monoclonal antibody, wherein the monoclonal antibody is operatively attached to the chelator, and a method of administering this composition to a patient having a fungal infection.

REFERENCES:
patent: 4054139 (1977-10-01), Crossley
patent: 4107121 (1978-08-01), Stoy
patent: 4411648 (1983-10-01), Davis et al.
patent: 4442133 (1984-04-01), Greco et al.
patent: 4569673 (1986-02-01), Tesi
patent: 4678660 (1987-07-01), McGary et al.
patent: 4749585 (1988-06-01), Greco et al.
patent: 4764164 (1988-08-01), Sasaki
patent: 4776334 (1988-10-01), Prionas
patent: 4847049 (1989-07-01), Yamamoto
patent: 4886505 (1989-12-01), Haynes et al.
patent: 4895566 (1990-01-01), Lee
patent: 4906238 (1990-03-01), Greenfield et al.
patent: 4917686 (1990-04-01), Bayston et al.
patent: 4952419 (1990-08-01), De Leon et al.
patent: 4973320 (1990-11-01), Brenner et al.
patent: 5002792 (1991-03-01), Vegoe
patent: 5013306 (1991-05-01), Solomon et al.
patent: 5037380 (1991-08-01), Jacobsen et al.
patent: 5071407 (1991-12-01), Termin et al.
patent: 5087240 (1992-02-01), Sibalis
patent: 5143071 (1992-09-01), Keusch et al.
patent: 5147291 (1992-09-01), Cukier
patent: 5202449 (1993-04-01), Hasagawa
patent: 5217493 (1993-06-01), Raad et al.
patent: 5324275 (1994-06-01), Raad et al.
patent: 5362754 (1994-11-01), Raad et al.
patent: 5542935 (1996-08-01), Unger et al.
patent: 5688516 (1997-11-01), Raad et al.
Tanaka, Chemical Abstracts, vol. 116, #102221, 1992.
Rodwell et al., Chemical Abstracts, vol. 112, #213574, 1990.
Adair et al., "Resistance of Pseudomonas to quaternary ammonium compounds," Applied Microbiology, 21(6):1058-1063, 1971.
AHFS Drug Information, McEvoy et al., editors, "Minocycline-HC1," pp. 318-319 and "Edetate Disodium," pp. 1805-1807, 1992.
Anwar et al., "Interaction of biofilm bacteria with antibiotics in a novel in vitro chemostat system," Antimicrobial Agents and Chemotherapy, 33(10):1824-1826, 1989.
Anwar et al., "Tobramycin resistance of mucoid pseudomonas aeruginosa biofilm grown under iron limitation," Journal of Antimicrobial Chemotherapy, 24:647-655, 1989.
Beaumont, "In-vivo experiments with ethylenediamine-tetra-acetic acid and investigations into its action of penicillin-resistant Staphylococcus aureus," The Medical Journal of Australia, pp. 1017-1020, 1970.
Benisek and Richards, "Attachment of metal-chelating functional groups to hen eggs white lysozyme," J. Biol. Chem., 243(16):4267-4271, 1968.
Berger et al., "Electrically generated silver ions: quantitative effects on bacterial and mammalian cells," Antimicrobial Agents and Chemotherapy, 9:357-358, 1976.
Brown and Foster, "Effect of slime on the sensitivity of Pseudomonas aeruginosa to EDTA and polymyxin," Journal of Pharmacy and Pharmacology (Abstract), British Pharmaceutical Conference, 108th Meeting, Glasgow, 23(Suppl.):236S, Sep. 13-17, 1971.
Brown, "Effects of the microbial environment on drug resistance," J. Sci. Fd Agric., 25:227-230, 1974.
Campbell, In: Monoclonal Antibody Technology, Laboratory Techniques in Biochemistry and Molecular Biology, vol. 13, Burden and Von Knippenberg, (Eds.), Amsterdam, Elseview, Chapter 3, pp. 75-83, 1984.
Clumeck et al., "Treatment of severe staphylococcal infections with a rifampicin-minocycline association," Journal of Antimicrobial Chemotherapy, 13(Suppl. C):17-22, 1984.
Condamine et al., "Acquired sideroblastic anaemia during treatment of Wilson's disease with triethylene tetramine dihydrochloride," British Journal of Haematology, 83:166-168, 1993.
Crosby and Gump, "Activity of cefoperazone and two b-lactamase inhibitors, sulbactam and clavulanic acid, against bacteroides spp. correlated with b-lactamase production," Antimicrobial Agents and Chemotherapy, 22(3):398-405, 1982.
Dankert and Schut, "The antibacterial activity of chloroxylenol in combination with ethylenediaminetetra-acetic acid," Journal of Hygiene, 76(1):11-22, 1976.
Davis and Iannetta, "Influence of serum and calcium on the bactericidal activity of gentamicin and carbenicillin on Pseudomonas aeruginosa," Applied Microbiology, 23(4):775-779, 1972.
Delmotte et al., "Study of the sensitivity of pyocyanic bacillus (Pseudomonas aeruginosa) to antiseptics and antibiotics. IV. Synergism or antagonism between antiseptics [French]," Therapie, 27(3):445-455, 1972.
DeRiemer et al., "BLEDTA: Tumor localization by a bleomycin analogue containing a metal-chelating group," J. Med. Chem., 22:1019-1023, 1979.
Dialog Search Report printed in USA in 1992.
Dickinson and Lewandowski, "Manganese bifouling and the corrosion behavior of stainless steel," Biofouling 10(1-3);79-93, 1996.
Diver et al., "The accumulation of five quinolone antibacterial agents by Escherichia coli," Journal of Antimicrobial Chemotherapy, 25:319-333, 1990.
Doss et al., "Effect of EDTA on bacterial resistance to antibiotics, a bacteriological and clinical study," Journal of the Egyptian Medical Association, 52(11):929-941, 1969.
Evans and Holmes, "Effect of vancomycin hydrochloride on staphylococcus epidermidis biofilm associated with silicon elastomer," Antimicrobial Agents and Chemotherapy, 31(6):889-894, 1987.
Farber et al., "Staphylococcus epidermidis extracted slime inhibits the antimicrobial action of glycopeptide antibiotics," Journal of Infectious Diseases, 161:37-40, 1990.
Farca et al., "Potentiation of the in vitro activity of some antimicrobial agents against selected gram-negative bacteria by EDTA-tromethamine," Veterinary Research Communications, 17(2):77-84, 1993.
Flowers et al., "Efficacy of an attachable subcutaneous cuff for the prevention of intravascular catheter-related infection," Journal of the American Medical Association, 261:878-883, 1988.
Fuursted, "Synergism and mechanism of subinhibitory concentration of streptomycin on Streptococcus faecalis," APMIS, 97:27-32, 1989.
Gefter et al., "A simple method for polyethylene glycol-promoted hybridization of mouse myeloma cells," Somatic Cell Genet., 3:231-236, 1977.
Gelewitz et al., "Some quantitative aspects of the reaction of diazonium compounds with serum albumin," Arch. Biochem. Biophys., 53:411-424, 1954.
Gerberick and Castric, "In Vitro Susceptibility of Pseudomonas aeruginosa to Carbenicillin, Glycine, and Ethylenediaminetetraacetic Acid Combinations," Antimicrobial Agents and Chemotherapy, 17(4):732-735, 1980.
Goding, 1986, In: Monoclonal Antibodies: Principles and Practice, 2nd ed., Academic Press , Orlando, FL, pp. 60-74, 1986.
Goodman and Gilman's The Pharmacological Basis of Therapeutics, Eighth Edition, Pergamon Press, Chapter 48, "Antimicrobial Agents," pp. 1117-1125, 1607-1608, 1990.
Goodwin et al., ".sup.111 In-labeled radiopharmaceuticals and their clinical use, " In: Radiopharmaceuticals, Society of Nuclear Medicine, New York, p. 80-101, 1975.
Gu and Neu, "In vitro activity of dactimicin, a movel pseudodisaccharide aminoglycoside, compared with activities of other aminoglycosides," Antimicrobial Agents and Chemotherapy, 33(11):1998-2003, 1989.
Harper and Epis, "effect of chlorhexidine/edta/tris against bacterial isolates from clinical specimens," Microbios, 51:107-112, 1987.
Henrickson and Dunne, Jr., "Modification of central venous catheter flush solution improves in vitro antimicrobial activity," The Journal of Infectious Diseases, 166:944-946, 1992.
Hnatowich et al., "Radioactive labeling of antibody: a simple and efficient method, " Science, 220:613-615, 1983.
Houlsby et al., "Effects of preservatives, steroids, and ethylenediaminetetraacetate on the antimicrobial activity of sulfacetamide," Journal of Pharmaceutical Sciences, 72(12):1401-1403, 1983.
Hoyle et al., "The biofilm glycocalyx as a resistance factor," Journal of Antimicrobial Chemotherapy, 26:1-6, 1990.
Inman et al., "Determination of EDTA in vancomycin by liquid chromatography with absorbance rati

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

EDTA and other chelators with or without antifungal antimicrobia does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with EDTA and other chelators with or without antifungal antimicrobia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and EDTA and other chelators with or without antifungal antimicrobia will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-991809

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.