Edrophonium-atropine composition and therapeutic uses thereof

Details Edrophonium-atropine composition and therapeutic uses thereof Edrophonium-atropine composition and therapeutic uses thereof

1988-10-18

1990-08-28

Lipovsky, Joseph A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514821, A61K 3144

Patent

active

049525867

ABSTRACT:
A composition is provided which includes a balanced combination of an edrophonium component and an atropine component. A preferred embodiment has 0.5 mg of edrophonium chloride and 8 micrograms of atropine sulfate, with respect to patient weight. The inventive composition is useful to antagonize nondepolarizing blockade during medical treatment when muscle relaxation is no longer necessary, provides extremely rapid onset of action and results in minimal heart rate changes.

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Cronnelly, et al., Br. J. Anaesth., vol. 54, pp. 183-194 (1982).
Ferguson, et al., Anesthesiology, vol. 53, No. 5, pp. 390-394 (Nov. 1980).
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Remington's Pharmaceutical Sciences 16th ed., pp. 838-840, 850-853 (1980).
A. R. Hunter, "Tensilon: A New Anti-Curare Agent", British Journal of Anaesthesia, 24: 175-186 (1952).

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