Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-04-24
1999-06-15
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 530350, 536 235, 536 243, C07K 14705, C12N 1512, C12N 510
Patent
active
059121440
ABSTRACT:
The present invention provides a new edg-1 like receptor (NEDG) and polynucleotides which identify and encode NEDG. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of NEDG.
REFERENCES:
Lau, L.F. and Nathans, D. "Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: Coordinate regulation with c-fos or c-myc" Proc.Natl.Acad.Sci.USA (1987) 84:1182-1186.
Lee, M. et al., "The Inducible G Protein-coupled Receptor edg-1 Signals via the G.sub.1 /Mitogen-activated Protein Kinase Pathway" J.Biol.Chem. (1996) 271:11272-11279.
Hla, T. and Maciag, T. "An Abundant Transcript Induced in Differentiating Human Endothelial Cells Encodes a Polypeptide with Structural Similarities to G-protein-coupled Receptors" J.Biol.Chem. (1990) 265:9308-9313.
Kobilka, B.K. et al., "Chimeric .alpha..sub.2 -, .beta..sub.2 -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity" Science (1988) 240:1310-1316.
Conklin, B.R. and Bourne, H.R. "Structural Elements of G.alpha. Subunits That Interact with G.beta..gamma., Receptors, and Effectors" Cell (1993) 73:631-641.
Hla, T. and Maciag, T. (GI 181948), GenBank Sequence Database (Accession M31210), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Database Embl, Entry No. MM1170779, Accession No. AA254425, Mar. 18, 1997.
Adams et al., "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence", Nature, 377:3-17 (1995).
Lado et al. Cloning of the rat edg-1 immediate-early gene: expression pattern suggests diverse functions. Gene 149:331-336, 1994.
Au-Young Janice
Guegler Karl J.
Billngs Lucy J.
Incyte Pharmaceuticals Inc.
Mohan-Peterson Sheela
Ulm John
LandOfFree
Edg-1-receptor homolog does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Edg-1-receptor homolog, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Edg-1-receptor homolog will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-401981