Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2006-01-10
2006-01-10
Wilson, James O. (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S051000, C514S912000
Reexamination Certificate
active
06984629
ABSTRACT:
Based on research for compounds that can display a corneal epithelial migration promoting effect in ophthalmology, the present invention provides P2Y receptor agonist corneal epithelial migration promoters, such as phosphoric acid compounds having an adenosyl group, uridyl group, xanthosyl group, guanosyl group, or thymidyl group, or their salts, with excellent corneal epithelial migration promoting effects.
REFERENCES:
patent: WO 98/34942 (1998-08-01), None
patent: WO 99/61012 (1999-12-01), None
patent: WO 00/50024 (2000-08-01), None
patent: PCT/JP01/04520 (2001-08-01), None
Kimura K. et. al., Effects of ATP and its analogues on (Ca2 + dynamics in the rabbit cornealepithelium., Archives of Histology and Cytology, May 1999, vol. 62, No. 2, p. 129-38, whole document, especially Summary).
Cha Seok Ho et. al., Purinoceptor-Medicated Calcium Mobilization and Cellular Proliferation in Cultured Bovine Corneal Endothelial Cells,Japanese Journal of Pharmacology, Mar. 2000, vol. 82, 181-187, whole document, especially Abstract, Fig. 6 and Discussion.
Kimura K. et. al., Effects of ATP and its analogues on [Ca2+]i dynamics in the rabbit corneal epithelium,Archives of Histology and Cytology, May 1999, vol. 62, No. 2, p. 129-38, whole document, especially summary.
Fujihara Tsutomu
Fujita Hiromi
Nakamura Masatsugu
Nakata Katsuhiko
Howrey LLP
Inspire Pharmaceuticals Inc.
King Viola T.
Owens, Jr. Howard V.
Santen Pharmaceutical Co. Ltd.
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