Ecteinascidins 736 and 722

Details Ecteinascidins 736 and 722 Ecteinascidins 736 and 722

1990-11-30

1992-09-22

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D51522

Patent

active

051498049

ABSTRACT:
Ecteinascidins 722 and 736 (Et's 722 and 736) have been isolated from the Caribbean tunicate Ecteinascidia turbinata and their structures have been assigned as tetrahydro-.beta.-carboline-substituted bis(tetrahydro- isoquinolines) related to the previously reported Et's 729 and 743. Et's 722 and 736 protect mice in vivo at very low concentrations against P388 lymphoma, B16 melanoma, and Lewis lung carcinoma.

REFERENCES:
Rinehart et al., Journal of Natural Products, vol. 53, No. 4, pp. 771-792 Jul. Aug. 1990.
Rinehart et al., Pure & Appl. Chem., vol. 62, No. 7, pp. 1277-1280 (1990).
Wright et al., J. Org. Chem., 55, 4508-4512 (1990).
Rinehart et al., J. Org. Chem., 55, 4512-4515, (1990).
Rinehart et al., Chem. Abstr., 109: 811j (1988).
Ito, CRC Crit. Rev. Anal. Chem., 17: 65-143 (1986).
Nakagawa et al., J. Amer. Chem. Soc., 111: 2721-2722 (1989).
The Merck Index, 11th Edition, page 1540, Monograph No. 9705 (1989).
Lichter et al., Food and drugs from the sea proceedings (1972), Marino Technology society, Washington, D.C. 1973 pp. 117-127.

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