Ecotin as a factor Xa, XIa, and XIIa inhibitor

Details Ecotin as a factor Xa, XIa, and XIIa inhibitor Ecotin as a factor Xa, XIa, and XIIa inhibitor

1993-12-10

1996-12-17

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435212, 4352521, 514 2, 514 12, 530350, 530825, 930250, A61K 3855, C07K 14245, C12N 950, C12N 964

Patent

active

055852599

ABSTRACT:
Pharmaceutical composition containing Ecotin in a therapeutically effective amount for inhibition of blood coagulation.

REFERENCES:
Chung, C. H. et al. J. Biol. Chem. 258:11032-11038 (1983).
McGrath, M. E. et al. J. Mol. Biol. 222:139-142 (1991).
Seymour, Jana L., et al.: "Ecotin Is a Potent Anticoagulant and Reversible Tight-Binding Inhibitor of Factor Xa", Biochemistry 33:3949-3958 (1994).
Kurz et al., Thrombosis Research 60:269-280 (1990), "Rat Model of Arterial Thrombosis Induced by Ferric Chloride".
Remington's Pharmaceutical Sciences, Mack Publishing Co. (A. R. Genarro, editor) (1985).

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