Eck receptor ligands

Details Eck receptor ligands Eck receptor ligands

1997-10-28

2000-07-11

Achutamurthy, Ponnathapura

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435366, 435368, 435353, 514 12, C12N 500, C12N 508, C12N 506, A61K 3800

Patent

active

060871679

ABSTRACT:
Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment using eck receptor ligands and soluble eck receptor and disclosed, as are pharmaceutical compositions containing same. A rapid and sensitive method for the detection of receptor binding activity in crude samples is provided.

REFERENCES:
Bartley et al., Nature 368, 558-560 (1994).
Shao, et al., J. Biol. Chem. 270, 5636-5641 (1995).
Pandey et al., Science 268, 567-569 (1995).
Takahashi et al., Oncogene 11, 879-883 (1995).
Magal et al., J. Neurosci. Res. 4 3, 735-744 (1996).
Lindberg, Tyrosine Phosphorylation & Cell Signalling, Cold Springs Harbor, New York (May 3-May 7, 1995).

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