Echo contrast agent for left heart opacification and method of u

Details Echo contrast agent for left heart opacification and method of u Echo contrast agent for left heart opacification and method of u

1994-04-11

1995-01-31

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

12866001, 12866202, A61B 800

Patent

active

053857259

ABSTRACT:
An echo contrast agent for use in echocardiography is disclosed which can be introduced into the body through peripheral venous injection to opacify left ventricle. The echo agent to be injected into the body contains a plurality of gas-in-liquid microbubbles which are smaller than red blood cells and can therefore traverse the pulmonary circulation to reach the left ventricle in substantial quantity to effectuate opacification thereof. The echo contrast agent disclosed in this invention contains: (a) an aqueous solution containing 0.40-0.60 grams of albumin and 4.0-10.0 grams of glucose per 10 ml solution mixed with (b) glycerin. The ratio between (b) and (a) should be no less than 0.050. A method for preparing this echo contrast agent was also disclosed.

REFERENCES:
patent: 4466442 (1984-08-01), Hilmann et al.
patent: 4957656 (1990-09-01), Cerny et al.
Feinstein et al, J. Am. Coll. Cardiol., vol. 16 (1990) pp. 316-324.
Smith et al, J. Am. Coll. Cardiol., vol. 13 (1989) pp. 1622-1628.
Berwing et al, Am. Heart J., vol. 115 (1988) pp. 399-408.
Lin et al, Paper presented at 63rd Sci. Sessions of the Am. Heart Asso. (Dec. 13, 1990).

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