Echinocandin process

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides

Reexamination Certificate

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Details

C530S318000, C530S338000, C530S339000, C514S002600, C514S009100, C514S011400, C930S270000, C930SDIG722, C930SDIG722

Reexamination Certificate

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10474893

ABSTRACT:
This invention relates to an improved process for the minimization of acid-catalyzed reactions of certain echinocandins of the kind disclosed in U.S. Pat. No. 5,378,804. The process involves the use of a boronic acid.

REFERENCES:
patent: 5378804 (1995-01-01), Balkovec et al.
patent: 5552521 (1996-09-01), Belyk et al.
patent: 5936062 (1999-08-01), Leonard et al.
patent: 5939384 (1999-08-01), Hammond et al.
M. Journet, et al., Semisynthesis of an Antifungal Lipopeptide Echinocandin, 1999, 2411-2417, 64.

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