Easters of acyl L-carnitines with gamma-hydroxybutyric acid and

Details Easters of acyl L-carnitines with gamma-hydroxybutyric acid and Easters of acyl L-carnitines with gamma-hydroxybutyric acid and

1995-02-28

1996-07-09

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560170, A16K 3122

Patent

active

055345492

ABSTRACT:
The esters of acyl L-carnitines with gamma-hydroxybutyric acid in the form of pharmacologically acceptable salts of formula (I) ##STR1## wherein X.sup.- is the anion of a pharmacologically acceptable salt, e.g. chloride, bromide, orotate, acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxalate, acid sulfate and glucosephosphate or in the form of inner salts of formula (I') ##STR2## wherein R is a straight or branched acyl group having from 2 to 5 carbon atoms, such as e.g. acetyl, propionyl, n,butyryl, isobutyryl and isovaleryl, are active in inhibiting neuronal degeneration (as it occurs in Alzheimer's senile dementia and Parkinson's disease) and in the treatment of coma.

REFERENCES:
patent: 4439438 (1984-03-01), Cavazza
patent: 5412113 (1995-05-01), Giannessi
"Hackh's Chemical Dictionary,"4.sup.th Ed., pp. 16, 85 & 86 (1972).
"Cecil Textbook of Medicine,"19.sup.th Ed., 2, pp. 2075-2079 2013-2133 (1993).

Affiliated with

Also associated with

Rating

Easters of acyl L-carnitines with gamma-hydroxybutyric acid and does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Easters of acyl L-carnitines with gamma-hydroxybutyric acid and , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Easters of acyl L-carnitines with gamma-hydroxybutyric acid and will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1867599