Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Reexamination Certificate
2006-06-06
2006-06-06
Falk, Anne-Marie (Department: 1632)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
C435S325000, C435S366000
Reexamination Certificate
active
07056738
ABSTRACT:
Marrow stromal cells (MSCS) are adult stem cells from bone marrow that can differentiate into multiple non-hematopoietic cell lineages. Colonies of human MSCs were shown to contain both small, rapidly self-renewing stem cells (RS cells) and large, more mature cells (mMSCs). Samples enriched for RS cells had a greater potential for multipotential differentiation than samples enriched for mMSCs. Also, RS cells have a series of surface epitopes and expressed proteins that can be used to differentiate RS cells from mMSCs. The results suggest that it will be important to distinguish the two major sub-populations of MSCs in defining their biology and their potentials for cell and gene therapy.
REFERENCES:
Deans et al. (2000) Mesenchymal stem cells: Biology and potential clinical uses. Exp. Hematology 28: 875-884.
Azizi et al. 1998, Proc. Natl. Acad. Sci USA 95:3908-3913.
Beresford et al. 1992, J. Cell Sci. 102:341-351.
Bruder et al. 1997, J. Cell Biochem 64:278-294.
Caplan et al. 1991, J. Orthoped 9:641-650.
Castro-Malaspina et al. 1981, Blood, 56:289-301.
Chopp et al. 2000, Neuroreport II:3001-3005.
Colter et al. 2000, Proc. Natl. Acad. Sci 97:3213-3218.
DiGirolamo et al. 1999, Br. J. Haematol 107:275-281.
Ferrari et al. 1998, Science 279:1528-1530.
Friedenstein et al. 1970, Cell Tissue Kinet 3:393-403.
Goodell et al. 1997, Nat. Med. 3:1337-1345.
Gronthos et al. 1999, J. Bone Miner. Res. 14:47-56.
Hou et al. 1999, Proc. Natl. Acad. Sci. 96:7294-7299.
Jackson et al. 1999, Proc. Natl. Acad. Sci 96:14482-14486.
Johnstone et al. 1998, Exp. Cell Res. 238:265-272.
Clark et al. 1995, Ann N.Y. Acad. Sci. 770:70-78.
Kopen et al. 1999, Proc. Natl. Acad. Sci USA, 96:10711-10716.
Kuznetsov et al. 1997, Br. J. Haematol 97:561-570.
Mets et al. 1985, Mech, Ageing Dev. 16:81-89.
Nilsson et al. 1999, J. Exp. Med. 189:729-734.
Pereira et al. 1995, Proc. Natl. Acad. Sci. USA 92:4857-4861.
Piersma et al. 1985, Exp. Hematol 13:237-243.
Pittenger et al. 1999, Science 284:143-147.
Prockop et al. 1997, Science 276:71-74.
Wakitani et al. 1995, Muscle Nerve 18:1417-1426.
Walsh et al. 2000, Bone 27:185-195.
Woodbury et al. 2000, J. Neuroscience Res. 61:364-370.
Colter David C.
Prockop Darwin J.
Sekiya Ichiro
Drinker Biddle & Reath LLP
Falk Anne-Marie
Philadelphia Heath and Education Corporation
Tulane University
LandOfFree
Early stage multipotential stem cells in colonies of bone... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Early stage multipotential stem cells in colonies of bone..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Early stage multipotential stem cells in colonies of bone... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3631822