Early diagnosis of cancerous and precancerous conditions by...

Details Early diagnosis of cancerous and precancerous conditions by... Early diagnosis of cancerous and precancerous conditions by...

2005-03-29

2005-03-29

Ungar, Susan (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S007100, C435S007230, C435S010000, C435S012000, C435S127000

Reexamination Certificate

active

06872517

ABSTRACT:
The present invention involves the early diagnosis of cancerous or precancerous conditions in the gastrointestinal tract by detection of a backleak of signature proteins or carbohydrates in a biological sample obtained from the gastrointestinal tract.

REFERENCES:
patent: 5605840 (1997-02-01), Meddings et al.
patent: 5620899 (1997-04-01), Meddings et al.
patent: 6251681 (2001-06-01), Davies et al.
patent: 6407058 (2002-06-01), Staddon et al.
Tockman et al (Cancer Res., 1992, 52:2711s-2718s).*
Achkar et al (Am. J. Gastroenterology, 1988, 83/3 (291-294).*
Freshney (Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, NY, p. 4).*
Dermer (Bio/Technology, 1992, 12:320).*
Drexler et al (Leukemia and Lymphoma, 1993, 9:1-25).*
Zellner et al (Clin. Can. Res., 1998, 4:1797-1802).*
Hsu (in Tissue Culture Methods and Applications, Kruse and Patterson, Eds., 1973, Academic Pres, NY, see abstract, p. 764).*
Meddings JB et al, “Sucrose: A Novel Permeability Marker for Gastroduodenal Disease”,Gastroenterology1993:104:1619-1626.
Sutherland LR et al, “A simple, non-invasive marker of gastric damage: sucrose permeability”,The Lancet1994;343:998-1000.
Mullin JM et al, “Different Size Limitations for Increased Transepithelial Paracellular Solute Flux Across Phorbol Ester and Tumor Necrosis Factor-Treated Epithelial Cell Sheets”,J of Cellular Physiology1997;171:226-233.
Mullin JM et al, “Potential Interplay Between luminal Growth Factors and Increased Tight Junction Permeability in Epithelial Carcinogenesis”,J of Experimental Zoology1997;279:484-489.
Mullin JM et al, “Protein Kinase C Activation Increases Transepithelial Transport of Biologically Active Insulin”,Cancer Research1998;58:1641-1645.
Mullin JM et al, “Electrophysiological Differences in Normal Colon Mucosa from Diverticular Disease vs Cancer”,Digestive Diseases and Sciences2000;45(12):2374-2375.
Soler AP et al, “Increased tight junctional permeability is associated with the development of colon cancer”,Carcinogenesis1999;20(8):1425-1431.
Clarke H et al, “Modification of tight junction function by protein kinase C isoforms”,Advanced Drug Delivery Reviews2000;41:283-301.
Kawabata H et al, “Sucrose permeability as a means of detecting diseases of the upper digestive tract”,J Gastroenterol Hepatol1998;13(10):1002-6.
Meddings JB et al, “Sucrose Permeability: A Novel Means of Detecting Gastroduodenal Damage Noninvasively”,Am j Ther1995;2(11):843-849.
Wilairatana P et al, “Increased gastrointestinal permeability in patients withPlasmodium falciparummalaria”,Clin Infect Dis1997;24(3):430-5.
Martinez-Palomo A, “Ultrastructural modification of intercellular junctions between tumor cells”,In Vitro1970;6(1):15-20.
Davies RJ et al, “Epithelial impedance analysis in experimentally induced colon cancer”,Biophys J1987;52(5):783-90.
Davies RJ et al, “Sodium transport in a mouse model of colonic carcinogenesis”,Cancer Res1987;47(7):4646-4650.
Davies RJ et al, “Colonic epithelial impedance analysis in a murine model of large-bowel cancer”,Arch Surg1986;121:1253-1258.
Davies RJ et al, “Transmural electrical potential difference as an early marker in colon cancer”,ArchSurg 1986;121:345-350.
Davies RJ et al, “Detection of the Cancer-Prone Colon, Using Transepithelial Impedance Analysis”,Arch Surg1989;124:480-484.

Affiliated with

Also associated with

Rating

Early diagnosis of cancerous and precancerous conditions by... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Early diagnosis of cancerous and precancerous conditions by..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Early diagnosis of cancerous and precancerous conditions by... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3388733