Early detection of prostate cancer (CAP) by employing prostate s

Details Early detection of prostate cancer (CAP) by employing prostate s Early detection of prostate cancer (CAP) by employing prostate s

1995-02-24

1997-03-25

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 74, 435 792, 435 794, 435 795, 436 64, 436813, G01N 33574, G01N 3353

Patent

active

056143729

ABSTRACT:
The invention relates to a bioaffinity assay of prostate-specific antigen (PSA) comprising the measurement of either the concentration of total PSA (PSA-T), the concentration of free form of PSA (PSA-F) or the concentration of PSA complexed to alpha-1-antichymotrypsin (PSA-ACT), PSA-T being the sum of PSA-F and PSA-ACT. According to the invention, additionally the concentration of human glandular kallikrein (hGK-1) is measured. The concentrations of PSA-T and hGK-1 can be measured in one single assay or in separate assays. The sum of the concentrations of PSA-T and hGK-1 is used to determine the ratio a) PSA-F/(PSA-T+hGK-1) and/or b) PSA-ACT/(PSA-T+hGK-1). Both of these ratios are shown to have clinical utility for the discrimination of prostate cancer and benign prostatic hyperplasia.

REFERENCES:
patent: 4446122 (1984-05-01), Chu et al.
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Dialog Information Service, Accession No. 87-097947/14, Abstract of Japan No. 62-46263, published 28 Feb. 1987.
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Lilja, H., "A Kallikrein-Like Serine Protease in Prostatic Fluid Cleaves the Predominant Seminal Vesicle Protein," J. Clin. Invest. 76:1899-1903 (1985).
Lilja, H., "Prostate-Specific Antigen in Serum Occurs Predominantly in Complex with .alpha..sub.1 -Antichymotrypsin," Clin. Chem. 37:1618-1625 (1991).
Christenson, A. et al., "Serum Prostate Specific Antigen Complexed to .alpha.-Antitrypsin as an Indicator of Prostate Cancer," J. Urol. 150:100-105 (1993).
Henttu, P. et al., "Prostate-Specific Antigen and Human Glandular Kallikrein: Two Kallikreins of the Human Prostate," Ann. Med. 26:157-164 (1994).
Finlay, J.A. et al., "Development of an Immunoassay for Human Glandular Kallikrein," 1994 Fall Meeting Abstract Form, Society for Basic Urologic Research (Sep. 1994).

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