Early detection of mycobacterial disease using peptides

Details Early detection of mycobacterial disease using peptides Early detection of mycobacterial disease using peptides

2002-08-02

2010-10-05

Swartz, Rodney P. (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S009100, C424S009200, C424S130100, C424S164100, C424S168100, C424S184100, C424S185100, C424S234100, C435S007100, C435S007200, C530S300000, C530S350000

Reexamination Certificate

active

07807182

ABSTRACT:
A number of protein and glycoprotein antigens secreted byMycobacterium tuberculosis(Mtb) have been identified as “early” Mtb antigens on the basis early antibodies present in subjects infected with Mtb prior to the development of detectable clinical disease. Epitope-bearing peptide fragments of these early Mtb antigens, in particular of an 88 kDa secreted protein, GlcB (SEQ ID NO:106) and of Mtb antigen MPT51 (SEQ ID NO:107) have been identified. These peptides, variants thereof, peptide multimers thereof that include two or more repeats of one or more of the peptides, and fusion polypeptides that include early Mtb antigenic proteins, peptides or both, are useful in immunoassay methods for early, rapid detection of TB in a subject. Preferred immunoassays detect the antibodies in the subject's urine. Also provided are antigenic compositions, kits and methods to useful for detecting an early Mtb antibodies. The antigenic proteins and peptides are also used in vaccine compositions.

REFERENCES:
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patent: WO97/34149 (1997-09-01), None
E. O. E. Bassey et al., “Candidate Antigens for Improved Serodiagnosis of Tuberculosis,” Tubercle and Lung Disease, 1996, pp. 136-145, vol. 77.

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