Early detection of Borrelia infection

Details Early detection of Borrelia infection Early detection of Borrelia infection

1996-06-06

1999-11-16

Gitomer, Ralph

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 724, C12Q 104

Patent

active

059855959

ABSTRACT:
A method for screening for Lyme borreliosis and other infectious diseases early in the course of the disease are disclosed. It has been found that there is a dramatic difference in surface binding of cultured infectious agents to naturally occurring polymorphonuclear leukocytes (PMNs) (e.g., neutrophils) between infected and noninfected animals, which may be present early in the course of the disease, before measurable antibody response. This binding response can be rapidly and accurately distinguished and quantitated using various detection techniques. The method involves visualizing the surface binding of the cultured infectious agent to naturally-occurring PMN to detect the infection.

REFERENCES:
patent: 4652521 (1987-03-01), Confer et al.
patent: 4888276 (1989-12-01), Shelburne
Benach J., Interactions of Phagocytes with the Lyme Disease Spirochete: Role of the Fc Receptor, J of Infectious Diseases, 150(4) 497-507, Oct. 1984.
Golightly M., The Laboratory Diagnosis of Lyme Borreliosis, Laboratory Medicine 21(5) 299-304, May 1990.

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