Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-08-02
1999-01-12
Huff, Sheela
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 79, 435 791, 435 792, 435 793, 435 794, 435 795, 435325, 435326, 435330, 435331, 4353441, 435810, 435960, 435975, 435 696, 435 697, 436518, 436547, 436548, 436 64, 436813, 530327, 530328, 530329, 530330, 5303873, 5303877, 5303879, 5303881, 53038873, 530808, 530809, 530867, 935 89, 935 93, G01N 33567, G01N 3353, G01N 33543, C07K 1600
Patent
active
058586822
ABSTRACT:
A monoclonal antibody which specifically binds with an E2A/pbx1 fusion epitope.
REFERENCES:
patent: 5328837 (1994-07-01), Godowski et al.
Antibodies, eds. Harlow and Lane, p. 76, 1988.
Berendes et al., "Specific immunologic recognition of the tumor-specific E2A-PBX1 fusion-point antigen in t(1;19)-positive pre-B cells," Leukemia 9:1321-1327 (1995).
Carroll et al., "Pre-B Cell Leukemia Associated with Chromosome Translocation 1;19," Blood 63:761-764 (1984).
Dedera et al., "Chimeric Homeobox Gene E2A-PBX1 Induces Proliferation, Apoptosis, and Malignant Lymphomas in Transgenic Mice," Cell 74:833-843 (1993).
Henthorn et al., "Two Distinct Transcription Factors That Bind the Immunoglobulin Enhancer .mu.E5/.kappa.E2 Motif," Science 247:467-470 (1990).
Hu et al., "HEB, a Helix-Loop-Helix Protein Relates to E2A and ITF2 That Can Modulate the DNA-Binding Ability of Myogenic Regulatory Factors," Molecular Cell Biology 12:1013-1042 (1992).
Hunger et al., "The t(1;19) (q23;p13) Results in Consistent Fusion of E2A and PBX1 Coding Sequences in Acute Lymphoblastic Leukemias," Blood 77:687-693 (1991).
Izraeli et al., "Unexpected Heterogeneity in E2A/PBX1 Fusion Messenger RNA Detected by the Polymerase Chain Reaction in Pediatric Patients with Acute Lymnphoblastic Leukemia," Blood 80:1413-1417 (1992).
Jacobs et al., "E2A Expression, Nuclear Localization, and In Vitro Formation of DNA-and Non-DNA-Binding Species during B-Cell Development," Molecular Cell Biology 13:7321-7333 (1993).
Kadesch, "Helix-loop-helix proteins in the regulation of immunoglobulin gene transcription," Immunology Today 13:31-36 (1992).
Kamps et al., "The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-PBX1 fusion proteins with differing transforming potentials," Gene & Development 5:358-368 (1991).
Kamps et al., "A New Homeobox Gene Contributes the DNA Binding Domain of the t(1;19) Translocation Protein in Pre-B ALL," Cell 60:547-555 (1990).
LeBrun et al., "Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias," Oncogene 9:1641-1647 (1994).
Lu et al., "Both Pbx1 and E2A-Pbx1 Bind the DNA Motif ATCAATCAA Cooperatively with the Products of Multiple Murine Hox Genes, Some of Which are Themselves Oncogenes," Molecular Cell Biology 15:3786-3795 (1995).
Monica et al., "Transformation Properties of the E2a-Pbx1 Chimeric Oncoprotein: Fusion with E2a is Essential, but the Pbx1 Homeodomain is Dispensible," Molecular Cell Biology 14:8304-8314 (1994).
Murre et al., "Structure and function of the helix-loop-helix proteins," Biochem. Biophys. Acta 1218:129-135 (1994).
Nelson et al., "Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs," Gene & Development 4:1035-1043 (1990).
Nourse et al., "Chromosomal Translocation t(1;19) Results in Synthesis of a Homeobox Fusion mRNA That Encodes for a Potential Chimeric Transcription Factor," Cell 60:535-545 (1990).
Numata et al., "New E2A/PBX1 Fusion Transcript in a Patient with t(1;19)(q23;p13) Acute Lymphoblastic Leukemia," Leukemia 7:1441-1444 (1993).
Ohno et al., "Acute Lymphoblastic Leukemia Associated with a t(1;19)(q23;p13) in an Adult," Internal Medicine 32:584-587 (1993).
Privitera et al., "Molecular Variants of the 1;19 Chromosomal Translocation in Pediatric Acute Lymphoblastic Leukemia (ALL)," Leukemia 8:554-559 (1994).
Van Dijk et al. "Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of the E2A in pre-B-cell acute lymphobloastoid leukemia," Proc. Natl. Acad. Sci. USA 90:6061-6065 (1993).
Williams et al., "New Chromosomal Translocations Correlate with Specific Immunophenotypes of Childhood Acute Lymphoblastic Leukemia," Cell 36:101-109 (1984).
Gruenwald Stefan
Monell Craig
Sang Bi-Ching
Huff Sheela
Pharmingen
LandOfFree
E2A/pbx1 fusion protein specific monoclonal antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with E2A/pbx1 fusion protein specific monoclonal antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and E2A/pbx1 fusion protein specific monoclonal antibodies will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1514136