E25a protein, methods for production and use thereof

Details E25a protein, methods for production and use thereof E25a protein, methods for production and use thereof

1997-09-05

2000-07-25

Huff, Sheela

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 500

Patent

active

060938005

ABSTRACT:
The invention provides a human E25a protein which is upregulated in cancerous cells, including those of hormone refractory prostate cancer, colon cancer, breast cancer or other cancers of epithelial origin. The invention also provides nucleic acid molecules encoding E25a protein, nucleic acid probes which hybridize with nucleic acid molecules encoding E25a protein, and antibodies which bind E25a protein. E25a protein and its related molecules can be useful as diagnostic markers of cancer, including hormone refractory prostate cancer, and as specific therapeutic targets in this disease. The invention also provides methods for diagnosing cancer, including hormone refractory prostate cancer.

REFERENCES:
Hillier, L., et al., "The WashU-Merck EST project, AC W37917," EMBL Database, Heidelberg, XP002058366. May 17, 1996.
Hillier, L., et al., "The WashU-Merck EST project AC N32815," EMBL Database, Heidelberg, XP002058367. Jan 13, 1996.
Deleersnijder, W., et al., "Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction," The Journal of Biochemical Chemistry, 271(32):19475-19482, XP002058368. Aug. 9, 1996.
Reiter, R., et al., "Representational difference analysis of human androgen independent prostate cancer," Proceedings of the American Association for Cancer Research, 37:246-247, XP002058557. Mar. 1996.
Raffo, A., et al., "Overexpression of bcl-2 protects prostate cancer cells form apoptosis in vitro and confers resistance to androgen depletion in vivo," Cancer Research, 55(19):4438-4445. XP002058467. Oct. 1, 1995.
Rinker-Schaeffer, C., et al., "Molecular and cellular changes associated with the acquisition of metastatic ability by prostatic cancer cells," The Prostate, 25(5):249-265, XP002058468. 1994.
Reiter, R., et al., "Two genes upregulated in androgen-independent prostate cancer are also selectively expressed in the basal cells of normal prostate epithelium," Journal of Urology, Supplement, 157(4):269, XP002058558. Apr. 4, 1997.

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