E2 binding proteins

Details E2 binding proteins E2 binding proteins

1994-12-22

1998-08-11

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530300, C07K 1400

Patent

active

057928339

ABSTRACT:
E2-BP polypeptides, nucleic acids encoding E2-BP polypeptides, and uses thereof.

REFERENCES:
patent: 5219990 (1993-06-01), Androphy et al.
patent: 5464936 (1995-11-01), Botchan et al.
Ushikai et al., "Trans activation by the full-length E2 proteins of human papillomavirus type 16 and bovine papillomavirus type 1 in vitro and in vivo: cooperation with activation domains of cellular transcription factors", J. Virology 68(10):6655-6666 (1994).
DelVecchio, A.M. et al. (1992) "Transient Replication of Human Papillomavirus DNAs" J. Virol. 66(10): 5949-5958.
Thierry F. and Yaniv M. (1987) "The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region" The EMBO J 6: 3391-3397.
Yang Y-C et al. (1985) "Dissociation of transforming and trans-activation functions for bovine papillomavirus type 1" Nature 318: 575-577.
McBride A.A. et al. (1991) "The papillomavirus E2 regulatory proteins" J. Biol. Chem. 266(26): 18411-18414.
Hwang E-S et al. (1993) "Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene" J. Virol. 67(7): 3720-3729.
Giri I. and Yaniv M. (1988) "Structural and mutational analysis of E2 trans-activating proteins of papillomaviruses reveals three distinct functional domains" The EMBO J. 7(9): 2823-2829.
McBride A.A. et al. (1989) "E2 polypeptides encoded by bovine papillomavirus type 1 form dimers through the common carboxyl-terminal domain: Transactivation is mediated by the conserved amino-terminal domain" PNAS USA 86: 510-514.
Winokur P. and McBride A.A. (1992) "Separation of the transcriptional activation and replication functions of the bovine papillomavirus-1 E2 protein" The EMBO J. 11(11): 4111-4118.
Adams et al. 1993 Nature Genetics 4:256-267.
Lefebvre et al. 1995 Cell 80:155-165.
Ardrophy et al 1993 J Invest. Dermatol. 100(4):526.
Breiding et al 1994 J Invest. Dermatol. 102(4):542.
Reeck et al. 1987 Cell 50:667.

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