(E-Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxides

Details (E-Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxides (E-Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxides

1984-11-14

1987-05-12

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 56, 514164, 514258, 514457, 514707, 514469, 514301, 568 22, A61K 31105

Patent

active

046650881

ABSTRACT:
This invention relates to compounds of the structures: ##STR1## which structure includes its isomers, conventionally designated (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide and commonly termed (E,Z)-ajoene. This invention also relates to a process for preparing the compounds which comprises extracting and isolating allyl disulfide oxide (allyl 2-propenethiosulfinate) from the bulbs of garlic plants and thereafter treating it with a lower alkyl alcohol to produce such compound and the compounds as antibiotic and particularly as antithrombotic agents.

REFERENCES:
patent: 2446072 (1948-07-01), Armstrong
patent: 2508745 (1950-05-01), Cavallito et al.
patent: 2554088 (1951-06-01), Cavallito
patent: 3336394 (1967-08-01), Lyness et al.
patent: 3428665 (1969-02-01), Aichenegg et al.
patent: 3819717 (1974-06-01), von Szczepanski et al.
The Practice of Aromatherapy, Jean Valnet, Destiny Books, NYC, 1982, ISBN 0-89281-026-2, p. 131.
Thrombosis Research, 1983, vol. 32, No. 2, pp. 156-169.

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