(E)-ethyl 3-(4-chloro-.alpha.-(4-methyl-1-piperazinyl)benzyl)cin

Details (E)-ethyl 3-(4-chloro-.alpha.-(4-methyl-1-piperazinyl)benzyl)cin (E)-ethyl 3-(4-chloro-.alpha.-(4-methyl-1-piperazinyl)benzyl)cin

1990-06-18

1992-06-23

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514255, A01N 4360, A61K 31495

Patent

active

051243300

ABSTRACT:
Potentiating agents which enhance the efficacy of antineoplastic agents are disclosed. The potentiating agents disclosed are piperazinyl benzyl compounds such as 1-[.alpha.-(4-chlorophenyl)-3-methoxybenzyl]-4-allylpiperazine dihydrochloride.

REFERENCES:
patent: 3996222 (1976-12-01), Kajfez et al.
patent: 4628047 (1986-12-01), Sakurai et al.
patent: 4757074 (1988-07-01), Coker et al.
patent: 4990538 (1991-02-01), Harris et al.
Wilson, C. M. et al., "Amplification of a Gene Related to Mammalian mdr Genes in Drug-Resistant Plasmodium falciparum," Science 244, 1184 (1989).
"The Merck Index," p. Misc-2 (11th Ed. 1989).

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