Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1992-03-25
1993-08-31
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
43525233, 4353171, 935 73, C12N 1500, C12N 1570
Patent
active
052408418
ABSTRACT:
A method for conferring resistance to a parasite to a host of the parasite, which comprises isolating a gene fragment from the parasite and inserting the gene fragment or a DNA or RNA segment substantially homologous to the gene fragment or to a DNA or RNA sequence functionally equivalent to the gene fragment into the host, wherein (1) transcription of the gene fragment or the DNA or RNA segment in the host occurs in an anti-sense direction, (2) the gene fragment or the DNA or RNA segment is expressed as a gene product in the host, wherein the gene product is capable of disrupting an essential activity of the parasite, or (3) the gene fragment or the DNA or RNA segment is a binding site capable of competing with a native binding site in the parasite, is disclosed along with hosts produced by this process. Particularly preferred is conferring resistance using a gene fragment from a replicase gene of an RNA virus.
REFERENCES:
Schumann et al. Gene 5:275-290, 1979.
Marcus et al. Dept. Microbiol. and Imm. A. Einstein College Med. pp. 185-196.
Zamecnik et al. PNAS 75:280-284, 1978.
Izant et al. Cell 36:1007-1015, 1989.
Wade et al. PNAS 76(9):4433-4437, 1979.
Fraley et al. PNAS 80:4803-4807, 1983.
E. Rhosu et al Chem Abst. 82(25): No. 166075w, 1975.
Kolakonsky et al. Chem Abst 75(23): No. 136414g, 1971.
Proc. Natl. Acad. Sci. USA vol. 81, pp. 1966-1970, Apr. 1984 "A Unique Mechanism Regulating Gene Expression: Translational Inhibition by a . . . ".
Nature vol., 314 Jun. 13, 1985 pp. 601-603 "A Novel Immune System Against Bacteriophage Infection Using Complementary RNA (micRNA)".
Johnston Stephen A.
Sanford John C.
Cornell Research Foundation Inc.
Duke University
LeGuyader J.
Schwartz Richard A.
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