E. coli O157:H7 C1 esterase inhibitor-binding protein and...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

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C435S069100, C435S069200, C435S007370, C536S023100, C536S023200, C530S300000, C530S350000

Reexamination Certificate

active

06872559

ABSTRACT:
Disclosed is a pO157 plasmid-specified polypeptide found inE. coliEDL933and other enterohemorrhagicE. colithat binds to and cleaves C1-esterase inhibitor. Also disclosed are methods employing the polypeptide for diagnosing and treating colitis or hemolytic uremic syndrome, and methods of detecting potential therapeutics.

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