E. coli O157:H7 bacteriophage and uses thereof

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...

Reexamination Certificate

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Reexamination Certificate



The present invention is directed to isolated bacteriophage having strong lytic activity against strains ofE. coliO157:H7, and methods of using that bacteriophage, and/or progeny or derivatives derived therefrom, to control the growth ofE. coliO157:H7 in various settings.

patent: 6485902 (2002-11-01), Waddell et al.
patent: 6544729 (2003-04-01), Sayler et al.
patent: 2002/0090356 (2002-07-01), Waddell et al.
patent: 2005/0175991 (2005-08-01), Sulakvelidze et al.
Morita et al., Characterization of a virulent bacteriophage specific forEscherichia coliO157:H7 and analysis of its cellular receptor and two tail fiber genes, FEMS Microbiology Letters, 2002, 211:77-83.
Mizoguchi et al., Coevolution of Bacteriophage PP01 andEscherichia coliO157:H7 in Continuous Culture, Applied and Environmental Microbiology, 2003, 69(1):170-176.
Zimmer, et al. (Aug. 2002) “Genomic analysis ofClostridium periringensbacteriophage phi3626, which integrates intoguaAand possibly affects sporulation.” Journal Bacteriology 184(16): 4359-68.
Zimmer, et al. (Nov. 2002) “The murein hydrolase or the bacteriophage phi3626 dual lysis system is active against all testedClostridium periringensstrains.” Applied Environmental Microbiology 68(11): 5311-7.
GenBank Accession No. EU588980 (Oct. 1, 2008).


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