(E)-5-(2-Halogenovinyl)-arabinofuranosyluracil, process for prep

Details (E)-5-(2-Halogenovinyl)-arabinofuranosyluracil, process for prep (E)-5-(2-Halogenovinyl)-arabinofuranosyluracil, process for prep

1980-12-12

1983-05-31

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 23, A61K 3170, C07H 1906

Patent

active

043860761

ABSTRACT:
A novel compound, (E)-5-(2-halogenovinyl)-arabinofuranosyluracil; a process for producing the same comprising reacting 5-vinylarabinofuranosyluracil with a halogen; and use of the same as an anti-DNA virus agent, especially anti-herpes virus agent and anti-varicella-zoster virus agent.

REFERENCES:
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Cheny, Y. et al., Antimicrobial Agents and Chemotherapy, vol. 18, pp. 957-961, 1980.
Sakata, S. et al., Nucleic Acids Research, Symposium Series No. 8; 539-542, 1980.
Machida, H. et al., Antimicrobial Agents and Chemotherapy, vol. 20, pp. 47-52, 1981.
Honjo, M. et al., Chem. Pharm. Bull., vol. 15, pp. 1076-1079, 1967.
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Renis, H., Cancer Research, vol. 30, pp. 189-194, 1970.
Barwolff, D. and Langen, P., Nucleic Acids Research, Special Publication No. 1, 529-531.
Bleackley, R. et al., Tetrahedron, vol. 32, pp. 2795-2797, 1976.
De Clercq, E. et al., Proc. Natl. Acad. Sci., vol. 76, pp. 2947-2951, 1979.

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